Living things that have had their DNA deliberately altered.
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- Mako (Face Off)
- Mako Shark (Deep Blue Sea)
- Monsieur Mallah
- Mamenchisaurus (Jurassic Park)
- Maurice (Rise of the Planet of the Apes)
- Mechanized German Soldier
- Mega Piranha
- Mel's Cyclops
- Meltdown's Experiments
- Mewtwo
- Microbe Swarm
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- Mook
- Mothmonsterman
- Mutant Lab Rat (Camp Camp)
- Mutant Scorpion
- Mutant Turkey (South Park)
- Mutated Ostrich (Courage the Cowardly Dog)
- Myrka
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- S.S. Doomtrooper
- Scorpius rex
- Servitor
- Sharktopus
- Sinoceratops (Jurassic Park)
- Sire
- Skunk Experiment
- Slattern
- Sleepyhead
- Snowball
- Spaghetti (Aqua Teen Hunger Force)
- Spider (Eight Legged Freaks)
- Spider (Ice Spiders)
- Spider Monkey
- Spinoceratops
- Spinosaurus (Jurassic Park)
- Stegosaurus (Jurassic Park)
- Nick Strangle
- Stygimoloch (Jurassic Park)
- Super Pig (Okja)
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