Others N/A
Personal information
Species Genetically-engineered hybrid
Gender Female (originally)
Male (later stage)
Relations Elsa Kast, Fred and Ginger, other subjects (DNA donors)
Current status Deceased
Height Same as human
Diet Carnivorous
Sentience Sentient
Sapience Sapient
Behind the Scenes
Universe Splice
Created by Vincenzo Natali and Antoinette Terry Bryant
Performed by Delphine Chanéac

The Dren is a human/animal hybrid created by two young, rebellious scientists in the science fiction horror movie Splice.


The Dren is a genetically-created hybrid chimera which combines human and animal DNA (later the human DNA revealed to be Elsa DNA). She was created by Clive Nicoli and Elsa Kast using a donated egg and previous chimera DNA from the creatures 'Fred and Ginger'.


It grows at a very rapid rate, and is quite an agile creature, sporting a tail (which is revealed to contain a regenerating stinger) and two hind-legs, as well as missing one digit on each hand, finally revealing a pair of wings and a barbed hood on the back of her neck, but otherwise appearing very human. Very intelligent in nature, picking up several words it spells out with letters on a board, and drawing, as well as a keen likeness to dance.

At maturity, it appears to be quite beautiful, even being successful in seducing several individuals before her predatory nature becomes apparent and she rebels by killing. Her final stage of growth resulted in its changing from female to male, and at the end of the film spokes its first, and only, two words ("Inside you"), before it is killed by Elsa Kast with a rock to the head.

After her/his death it is revealed that Elsa is pregnant, possibly from Dren because she was raped by him.


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